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The pathogenesis of this condition is complex, and various factors are believed to interact, including accumulation of drug metabolites, HLA-associated predisposition, drug-virus interactions, alternating cycles of immunosuppression and immune recovery, and the presence of drug-specific T lymphocytes.1 DRESS syndrome is a type IV hypersensitivity reaction that is mediated by type 2 helper T cells.2 We report the case of a 24-year-old man who attended the emergency department with a 2 to 3–day history of generalized erythematous maculopapular rash (Figs

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